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Age-related endothelial dysfunction is associated with a reduced bioavailability of l-arginine and reduction in eNOS synthesis [1,41,46]

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At the present level of our knowledge, it is safe to conclude that the orobuccal route can be used for treatment of hyperpigmentation with glutathione GSH at a dose of 100–400±50 mg per day for periods of between 10 and 12 weeks, depending upon indication, and it is hoped the treatment can be repeated to maintain effect