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A 2014 review by Seiwerth and colleagues in Current Pharmaceutical Design summarized the preclinical vascular effects attributed to BPC-157 and framed the mechanistic hypotheses that subsequent studies have tested

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In addition, a clinical trial has shown that the combination of estrogen and antidepressants is more effective in alleviating perimenopausal depression than estrogen or antidepressants alone (75,76)