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10.1172/JCI20660 [DOI] [PMC free article] [PubMed] [Google Scholar] 181.Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, et al

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Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction