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Reduce insulin levels Increased muscle glucose uptake → decreased blood sugar → decreased insulin secretion → relief of hyperinsulinemia: Insulin is a potent fat synthesis hormone, with a 30% -50% decrease in insulin levels leading to significant inhibition of fat synthesis

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We hypothesized that this lack of effect could be due to the fact that receptor-bound dKLAK-z13 localizes to the luminal side of endosomes, a prediction supported by the endosome-like pattern of fluorescent z13 (Fig

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