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Taken together, these data indicated clearly that IGF plays a central role in regulating follicular development via granulosa cell proliferation, differentiation, steroid production, and by mediating the stimulatory activity of gonadotropins

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In addition, lysine demethylase 4C (KDM4C) can also increase the expression of SSP genes by directly demethylating the promoter of SSP genes or ATF4, a transcriptional substrate of NRF2 (Denicola et al., 2015