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Gastroenterology , 2008 The practical implication is that KPV concentrates itself in inflamed tissue — PepT1 upregulation is essentially a homing signal — which is why nanomolar local concentrations are sufficient and why oral administration works for luminal GI pathology where most peptides fail

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Functional Divergence between Histone Deacetylases in Fission Yeast by Distinct Cellular Localization and In Vivo Specificity