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For patients who have exhausted conventional sleep interventions (sleep hygiene, CBT-I, conventional medications) and remain symptomatic, DSIP represents a speculative option with a plausible mechanism

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Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]