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It should however be noted that Cys residues are used for a wide range of functions – catalytic, regulatory, structural, and others – whereas the related amino acid selenocysteine (Sec, further discussed below) seems to be uniquely dedicated to the catalysis of redox reactions [29–32]

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Moreover, Gln is an essential substrate for the immune system, and prolonged use of Gln metabolic inhibitors might weaken the anti-tumor immune response ( 2 The role of Gln metabolism in tumor Emerging evidence shows that Gln metabolism is involved in tumor progression in two specific ways ( Figure 1 )