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IGF-I is only approved for treatment of patients with primary severe IGF-I deficiency or with GH gene deletion that have developed neutralizing antibodies to GH at a dose of 40–120 μg/kg twice daily subcutaneously

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However, current preclinical and clinical studies on probiotics in cancer prevention and treatment largely focus on their role as adjuvants to improve the efficacy and safety of chemotherapy and immunotherapy, rather than as standalone anticancer agents 11,12,13,14 , most likely due to the uncertain efficacy, mechanism, and safety in the complex human body