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A note on the topical comparison The most cited cosmetic-route reference, Gorouhi & Maibach (2009), sits well outside the 2023–2026 evidence window and predates current subcutaneous practitioner protocols
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Dermal edema and erythrocyte extravasation may be present, as well as spongiosis, a pseudolymphomatous reaction, and focal epidermal necrosis.43,44 Laboratory alterations Eosinophilia, in varying degrees, is one of the characteristics of the syndrome, is present in up to 95.5% of cases at some stage of the disease and may persist after the normalization of liver enzymes.32,45 Several cytokines are involved in the activation and recruitment of eosinophils
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