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Across this interface, there is: (a) a physical barrier formed by tight junctions between cells (visualized in Figure 4), (b) a barrier to transport, as a result of ion channels and other means of modulating solute flux, and (c) a metabolic barrier created by a suite of enzymes, which metabolize molecules that they contact

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10.3389/fpsyt.2020.572533 136 RazaK