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While these drugs help manage pain and inflammation, they do not change the degenerative process itself [37]

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IGF-I action is also essential as demonstrated by IGFIR rodent knock-out studies ( Igf1r −/− ) resulting in 55% reduction in fetal size (Milward et al., 2004), an effect also present in humans with mutations of IGF1R (Barclay et al., 2010)