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Platelet-rich plasma has multiple small human RCTs and systematic reviews supporting modest benefit in tendinopathy, giving it a higher evidence grade than BPC-157, which has only animal and mechanistic data

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Consequently, ID-ADCs may be misrouted to non-permissive compartments, resulting in insufficient payload release and impractically high dosing requirements ( 10.3 Structural and biochemical knowledge gaps Rational ID-ADC design is constrained by limited structural and biochemical data