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Published research links the peptide to cytoprotection, fibroblast migration, collagen organization, endothelial support, angiogenic signaling, nitric-oxide-pathway modulation, and tissue recovery, making it a prominent compound in regenerative research

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Mice which have been genetically engineered to lack Nrf2 protein are considerably more sensitive to chemical carcinogens, and also chemical toxins leading to increased inflammation in the lung and brain, all major markers of oxidative stress