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435 Sirolimus has also shown efficacy in rare diseases such as lymphangioleiomyomatosis (NCT00414648) and renal angiomyolipoma in tuberous sclerosis complex (TSC) (NCT00457808), 436,437 where mTOR-driven cell proliferation and dysregulated autophagy are key features

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The transition to human clinical trials remains a necessary step to confirm these findings