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Materials and methods Animals Wild type (WT) BALB/cJ, recombination-activating gene 2–deficient [Rag2 –/– , C.B6(Cg)-Rag2tm1.1Cgn/J, RRID: IMSR_JAX:008448], and Rag2-deficient γ chain–deficient (Rag2 –/– GC –/– , C;129S4-Rag2tm1.1FlvIl2rgtm1.1Flv/J, RRID: IMSR_JAX:014593) mice were obtained from The Jackson Laboratory

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CONTRA-INDICATIONS Do not administer to animals with seriously impaired renal functions