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This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function

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The GHK sequence was first isolated from human plasma in the 1970s and shown to bind copper with high affinity through coordination between the imidazole nitrogen of histidine, the α-amino nitrogen of glycine, and adjacent backbone atoms