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doi: 10.1016/j.xphs.2022.01.009

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Another study obtained crude caricain/papain from papaya latex, purified it, and demonstrated that treatment of wholegrain bread fermented at 30–37 °C from 5 to 7 h with purified caricain/papain managed to reduce up to 98% of the gliadin originally present, and that the purified enzyme worked better than its crude version [42]