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This condition leads to the formation of large, abnormal, and immature red blood cells and impaired DNA synthesis ( Like the condition called iron deficiency anemia, anemia related to B12 deficiency may make your skin pale due to a lack of fully-matured, healthy red blood cells in the body ( Headaches are among the most commonly reported symptoms related to B12 deficiency in both adults and kids ( A 2019 study with 140 people, half of whom experienced migraine, found that blood levels of B12 were significantly lower in the participants with migraine ( Research continues to investigate if treatment with B12 may improve migraine headache symptoms in some people ( Having low levels of B12 can cause elevated levels of a sulfur-containing amino acid called homocysteine