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Seek same-day medical care or go to an emergency department if you have: Severe abdominal pain that is constant or rapidly worsening A swollen, tender abdomen, especially with fever Heavy rectal bleeding or passing large amounts of blood Persistent vomiting and inability to keep fluids down Signs of dehydration — reduced urine, dizziness, very dry mouth Fever above 38.5°C with chills Sudden new severe perianal pain or swelling Sudden swelling, redness, or pain in a leg (possible blood clot) If you are on immune-suppressing treatment, fevers and infections deserve a lower threshold for review, because the usual signs of infection may be less obvious

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