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On the question of raw, proven efficacy for photoaging, the honest answer is that tretinoin has the stronger evidence base — but the picture is more nuanced than a simple winner-takes-all verdict

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Live cell imaging results showed that some cells exhibited a state of non-division or nonextension under Gln deficiency (Gln−) conditions, whereas cells grew plum and well under Gln sufficiency (Gln+) conditions (Fig