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Long-term use raises concerns about possible liver and kidney damage, though specific data on how often this happens remains limited

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Conversely, it has been shown that gliotoxin may substitute for 2-cys peroxiredoxin activity in HeLa cells by accepting electrons from NADPH via the thioredoxin reductase–thioredoxin redox system to reduce H 2 O 2 to H 2 O