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Independent of the trigger of neurodegeneration leading to AD, PD, HD or ALS, common pathological themes emerge: excitotoxicity, mitochondrial dysfunction, oxidative stress, glial and vascular dysfunction, often interacting in complex, cascading patterns

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The figure describes an in-vitro dendritic-spine assay in which picomolar Dihexa produced spine density comparable to nanomolar BDNF — a potency ratio in a specific cell-culture readout