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RT‐qPCR mRNA measurement In rats with stroke‐reperfusion at 1 and 24 hr, the beneficial effect of BPC 157 therapy during reperfusion was associated with strongly elevated ( Egr‐1, Akt‐1, Kras, Src, Foxo, Srf, Vegfr2, Nos1, and Nos3 ) and decreased ( Nos2 and Nfkb1 ) gene expression, while Mapk1 remained unchanged throughout both time intervals (Figure 6)

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It is generally agreed that we have no evidence that febuxostat is a negative for the heart, just the question of the CARES trial as to whether it is not as protective as allopurinol