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3.6.3.2 Microbial metabolites A substantial body of research highlights the role of gut microbiota and their metabolites, particularly SCFAs, in regulating metabolic, endocrine, and immune functions, with emerging evidence pointing to their involvement in neuro-immunoendocrine pathways through the MGBA (Silva et al., 2020)

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Cystine limitation induced the expression of AARE-containing genes in the ISR, which are involved in amino acid metabolism ( SLC7A11 , SLC7A1 and SLC38A2 ) and cell survival ( TRIB3 ) (Fig