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In vitro , in comparison with control, healthy animals, the assessment of splenic cells (day 21) demonstrated that the 6α-methylprednisolone animals had declined reactivity to nitrogen, while the addition of BPC 157 (1 μg/g cream) returned cell reactivity to normal values (Sikiric et al., 2003)
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47 Since then, the process has been improved by many groups and scientists such as Staudenmaier (1898), Hummers (1958), Shen (2009), Chen (2015), and many more by altering the oxidant, carbon source, and reaction temperature (Figure 1)
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