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2.2.3 The effects of ROS on synovial cells In OA, synovial cells play a critical role in both the production of ROS and the amplification of inflammatory responses (Mathiessen and Conaghan, 2017)

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Although a significantly elevated renal CAT activity in 6- and 16-week old, 22 and older SHR 8, 23 has been reported before, this is the first time that altered renal CAT expression and activity has been reported in pre-hypertensive SHR