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The findings reveal that gene polymorphisms are frequently associated with adverse effects for each immunosuppressant, including MTX ( MTHFR and ATIC ), AZA ( TPMT, NUDT15, ITPA, ABCC4 ), CYC ( CYP2C19, GSTM1, GSTT1, GSTP1, ALDH ), and MMF ( SLCO1B1, IMPDH1, UGT2B7 )