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[DOI] [PubMed] [Google Scholar] 44.Martinez M., Cuskelly G.J., Williamson J., Toth J.P., Gregory J.F., 3rd Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration

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slow infusion protocol described in controlled trials Intracisternal – Used in pain modulation studies in mice Subcutaneous injection – Referenced in some peptide research protocols Common Model Organisms DSIP has been studied across multiple preclinical species: Rabbits – Primary original discovery model