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[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, hypertonia was reported in 0% of patients receiving 50 mg/day and 3% of patients receiving 400 mg/day

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What exists instead is a set of preclinical observations from the same short-duration mouse studies used to test its metabolic effects, plus a small, separate body of research on NNMT’s role in cancer biology