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GSH is essential for cell survival as demonstrated by observations that glutamate cysteine ligase (GCL) knockout mice die from massive apoptotic cell death [117], and that the knockdown of GCL in distinct cell types induces time-dependent apoptosis [118,119]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Amin B.J.H., Kakamad F.H., Ahmed G.S., Ahmed S.F., Abdulla B.A., Mohammed S.H., Mikael T.M., Salih R.Q., Ali R.K., Salh A.M., et al