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Intravenous administration of lipoic acid at doses of 600 mg/day for three weeks (112) and oral lipoic acid at doses as high as 1,800 mg/day for six months (113) and 1,200 mg/day for two years (76) did not result in serious adverse effects when used to treat diabetic peripheral neuropathy

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Why “Non-Inferiority Not Met” Matters A non-inferiority trial asks whether a new treatment is not unacceptably worse than the comparator by a prespecified margin