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Some rare sermorelin side effects can include ( 6 ): Allergic reactions, such as rash, itching, or in severe cases, difficulty breathing Sleep disturbances, including vivid dreams or insomnia Water retention, bloating, or swelling in the hands and feet Joint pain or stiffness, particularly in the knees or ankles Tingling or numbness in the extremities These effects can sometimes be related to how the body processes increased GH levels