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SP remodels bone homeostasis in vitro via NRF2/KEAP1 signaling pathways NRF2 is a redox-sensitive transcription factor that codes for versatile cytoprotective proteins, including antioxidant, detoxification, and anti-inflammatory proteins 26

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GSH is unique in that it is one of the few antioxidants in the ELF that is expressed at higher levels than the plasma