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therefore, the activity of the enzyme in vivo may differ significantly from its activity in vitro, as the solution structure greatly affects the enzyme reaction rate [136]

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[DOI] [PubMed] [Google Scholar] Song YL, Jing WH, Yan R, and Wang YT (2014) Metabolic characterization of (+/−)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry