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Hippocampal neurons were then cultured a further 3-7 days, at which time they were either transfected or treated with various pharmacological reagents as described in (Wayman et al., 2008)

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1 Introduction Serine proteases account for more than one-third of known proteolytic enzymes and are important effectors in many essential physiologic functions, including blood coagulation, digestion, and host immunity ( Figure 1 )