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Ca²⁺ can originate from intracellular organelles or enter from the extracellular environment through specific ion channels, including Ca²⁺ release-activated Ca²⁺ channels, transient receptor potential (TRP) channels and L-type voltage-gated Ca²⁺ channels
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A 2025 review published in International Journal of Molecular Sciences summarized the mechanism precisely: thymic involution leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases, and Tα1 helps restore immune function by stimulating T-cell differentiation, enhancing thymic output, and modulating dendritic cell and macrophage activity.8 The Anti-Inflammatory Mechanism Tα1 operates primarily through Toll-like receptor (TLR) modulation, a master regulator of both innate and adaptive immunity
