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Symptoms can include: Muscle weakness or cramping Irregular heartbeat Unusual tiredness Heart failure symptoms (rare, mostly in those with underlying heart disease): Shortness of breath Swelling in ankles or feet Rapid weight gain Less Common Side Effects Acne-like skin rash Flushing or a feeling of warmth Joint pain Mild fever Special Precautions Consult your doctor before use if you have a history of allergies, kidney problems, or low potassium

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The first proposed mechanism is that GSH itself is a substrate for the Mrps, and preliminary studies in MRP1-containing proteoliposomes support this hypothesis