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Des(1–3)IGF-1 is a naturally occurring, endogenous truncated analogue of Insulin-like Growth Factor-1 (IGF-1), lacking the first three amino acids at the N-terminus of IGF-1, giving it a total of 67 amino acids compared to the 70 of native IGF-1

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Significant changes in TCA intermediates fumarate and succinate, and in the secondary TCA metabolites succinyl-carnitine and methyl succinyl-carnitine were observed, arguing that the potential anti-inflammatory properties of these metabolites are mediated by metabolic rewiring