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Their activation promotes waking status, induces SWS, or stimulates REM sleep depending on where 5-HT 1A receptors are located ( 1A receptors – mainly associated with mood and anxiety disorders ( 1A autoreceptors located in Dorsal Raphe Nuclei ( Animal studies suggest that L-theanine administration increases brain serotonin and dopamine levels ( Conversely, glutamate receptors are the main excitatory receptors in the central nervous system ( In order to confirm our findings on receptor and neurotransmitter level alterations which were shown to be effective on sleep regulation, we performed a sleep induction test by pentobarbital administration after compounds were given with or without caffeine
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