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61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

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Causes and Risk Factors The exact cause of fibromyalgia is unknown, but it is believed to involve a combination of genetic, environmental, and psychological factors Some potential triggers include: Genetics: Fibromyalgia tends to run in families, suggesting a genetic predisposition