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In proteins, specific hydrogen-bond donors and an electropositive local environment tend to lower the pK a by stabilizing the thiolate, and a hydrophobic environment or an electronegative local environment tends to raise the pK a by destabilizing a negatively-charged as opposed to neutral form of the side chain (for a few specific examples of these effects, see [14, 30–32])

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There were many studies suggesting an association between these factors and prostate cancer development, but there are still no unambiguous conclusive results