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Based on its mechanism as a monoamine reuptake inhibitor, contraindications include concurrent use of MAO inhibitors, uncontrolled hypertension, a history of serious cardiovascular disease, active eating disorders, and concurrent use of other serotonergic drugs due to serotonin syndrome risk

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A variety of xenobiotics such as phenobarbital, rifampicin, and hyperforin have been shown to induce transcriptional expression of CYP2C9 in primary human hepatocytes and to increase the metabolism of CYP2C substrates in vivo in man (17,18)

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