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Various stressors—including nociception-induced stress, chronic stress, and restraint stress—have been shown to cause melanocyte stem cell loss and hair graying through immunological mechanisms, corticosterone, and norepinephrine.22,23 Melanocyte stem cells express β2-adrenergic receptors, which respond to norepinephrine

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FDA also maintains an interim enforcement policy for certain Category 1 substances while it completes its evaluation process