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Among the 142 participants who had gadolinium-enhancing lesions on baseline MRI, a sign of residual focal inflammation, tolebrutinib cut progression risk by 65%

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When to seek medical advice: Persistent or worsening injection site reactions (increasing redness, warmth, or discharge suggesting infection) Severe or persistent headaches Chest pain or palpitations Unexplained muscle weakness or cramps New or worsening neurological symptoms despite treatment Unexpected bleeding or bruising For non-emergency concerns, contact your GP or NHS 111