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This work was supported by Key research and development program in Xinjiang Uygur Autonomous Region (2022B03002-2), Tianshan Talent Training Program (2023TSYCLJ0043) and Key R&D Program Project in Xinjiang, Research on Key Technologies for Quality Control at the Source of Ancient Classic Prescriptions (2022B03007-2)

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This early preclinical report demonstrates proof-of-principle that NMDAR antagonists may represent a new class of antidepressants