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28 , 29 On the other hand, this lead Selye to propose the concept that the most essential role of the “adrenotropic” principle in the coping response was to reestablish homeostasis 22 while two other principles, “thyrotropic” and “histaminergic,” remained less emphasized

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In cell culture systems, the upregulation of these heat shock proteins similarly caused reductive stress with increased GSH and decreased ROS [48, 49]