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A 2026 ex-vivo study in human internal mammary artery tissue (Yildirim et al., J Clin Med 15(9):3488, PMID 42123221) provided the first human-tissue mechanism evidence for BPC-157’s endothelium-dependent, nitric-oxide-mediated vasorelaxation — anchoring the previously preclinical NO-pathway literature in human ex-vivo data