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Enzyme-responsive biomaterial therapies for MI Currently, most enzyme-responsive biomaterials for MI treatment focus on targeting MMPs, a major family of proteinases upregulated in both serum and the cardiac interstitium at the end of inflammatory phase, due to its role in ECM degradation and myocardial remodeling 25

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18 If major depression is related to reduced GABA concentrations, then a corollary may be the idea that effective treatment for depression should normalize GABA