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In summary, depression remodels host lipid metabolism via TLR/PPAR-γ signaling and PUFA dysregulation, fostering an intracellular niche for Mtb survival while impairing anti-mycobacterial immunity

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For many practitioners and users, the optimal approach involves strategic selection based on current needs—or even combination protocols that leverage the unique benefits of each delivery method at different times of day or phases of treatment